Boos rang around the stadium when Lucas Moura was replaced by Steven Bergwijn in the second-half, and Nuno faced chants of ‘you don’t know what you’re doing’ as furious fans vented their anger.
While his job is not believed to be under any immediate danger, a defeat to Everton in their next Premier League game could well see under-fire Spurs chairman Daniel Levy pull the trigger on Nuno.
There is no doubt who would be the most popular choice among the Spurs fanbase, however – a certain Mauricio Pochettino.
The Argentinean was a much-loved figure during the five-and-a-half years he spent at the club between 2014-19, and many were shocked when he was sacked and replaced by Jose Mourinho.
Although he is now at Paris Saint-Germain, there is a belief that Pochettino could be tempted into a sensational return to north London – especially given the fact he is coming under fire at Parc des Princes.
And speaking to BT Sport last year, Pochettino did little to play down the suggestions that he has unfinished business at Spurs.
“Deep inside, I think maybe in five years, maybe in ten years, the universe will see that before I die I will manage Tottenham again,” he said.