Leicester City will be without both Jonny Evans and Caglar Soyuncu for the visit of Tottenham Hotspur on Thursday.
Both defenders are out with hamstring injuries, while Jannik Vestergaard and Filip Benkovic are still out through Covid or illness, manager Brendan Rodgers has confirmed.
Daniel Amartey has also returned to the squad but will not be available to start the match.
It leaves Rodgers with no fit recognised senior centre-backs for the match against Tottenham on Thursday.
It may be the case that Wilfred Ndidi fills in at centre-half, as he did from the fourth minute in the 4-0 win over Newcastle United on Sunday.
In total, City have 11 players out, with Evans, Soyuncu, Wesley Fofana, and James Justin injured, and with Vestergaard, Benkovic, Kelechi Iheanacho, Ayoze Perez, Hamza Choudhury, Ademola Lookman, and Vontae Daley-Campbell out with Covid or illness.
Speaking on injuries, Rodgers said at his pre-match press conference: “(Evans) not as bad as first feared. The scan has come through as best as we could have hoped for. He’ll struggle for tomorrow’s game and we’ll see where he’s at for the weekend.
“We’ve still got a number of players out. In terms of Covid, we’re still where we were. It’s a similar group of players that have been out that will continue to be out.
“Soyuncu has picked up an injury so he will be unavailable for the game as well. We’ll see where he’s at for the weekend. Again, it’s a player having to play more than we would want because of people unavailable.
“Daniel Amartey will be back, but’s only available after a period of time out, so we can’t consider him to start the game. Apart from that, it will be the same squad minus Jonny and Cags.
“We’ll see how his recovery goes over the next few days. It could be up to a week or so, 7 to 11 days maybe, it all depends on the individual, how they recover.
“It was right towards the end of the game, he’d gone up for a corner and was then sprinting back and right at the end of it, he put his hand down, and felt that issue in his hamstring. He’s played a lot of games. We’ll just have to assess it between now and the weekend.”
Young central defenders Ben Nelson and Lewis Brunt were on the bench for City at the weekend and could be called upon this week.
Full-backs Timothy Castagne and Ryan Bertrand have experience of playing in a back three, so that could be another option for Rodgers to consider.